The effect of A-PRP-therapy on reparative regeneration of bone tissue with acute bone fractures of the limbs
| Autor: | V. V. Ochkas, O. N. Ponkina, R. R. Aliev, A. S. Samoilova, A. A. Verevkin, M. L. Mukhanov, I. A. Rodin, A. N. Blazhenko |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty RD1-811 030204 cardiovascular system & hematology Bone tissue 03 medical and health sciences 0302 clinical medicine reparative osteogenesis medicine Diseases of the circulatory (Cardiovascular) system RC254-282 RC86-88.9 business.industry Regeneration (biology) platelet-rich plasma Neoplasms. Tumors. Oncology. Including cancer and carcinogens Medical emergencies. Critical care. Intensive care. First aid General Medicine 030104 developmental biology medicine.anatomical_structure regeneration RC666-701 Surgery business consolidation |
| Zdroj: | Инновационная медицина Кубани, Vol 0, Iss 3, Pp 32-38 (2019) |
| ISSN: | 2541-9897 2500-0268 |
| Popis: | Material and methodsThe study consisted of two parts – in the first part we studied the effect of A-PRP-therapy on the model of a comminuted fracture created in the operating room, an experimental study conducted on 40 Mature rabbits of the Flander breed, all animals were divided according to the principle of analogues into 2 groups (20 animals): in the study group – on the 5th day after osteotomy, platelet-rich plasma was injected into the fracture area, in the comparison group – the fusion occurred without the influence of any drugs. The second part presents the results of clinical testing of A-PRP-therapy, analyzed the results of treatment of 16 women with low-energy fractures of the distal radius metaepiphysis. The study group consisted of 6 patients whose surgical treatment was supplemented by A-PRP-therapy on 7, 14 days after surgery. The control group consisted of 10 patients who underwent surgical treatment without A-PRPtherapy.Results:The use of platelet-rich plasma to stimulate reparative osteogenesis in accute fractures reduces the time of fracture consolidation by 9.5±1.1%.ConclusionPlatelet-rich plasma (PRP) to stimulate reparative osteogenesis is an inexpensive, easy to perform and effective procedure. The possibilities of application of this technology in traumatology and orthopedics require further research in order to create protocols for the Use of a-PRP-therapy to stimulate the maturation of bone calluses. Results The use of platelet-rich plasma to stimulate reparative osteogenesis in accute fractures reduces the time of fracture consolidation by 9.5±1.1%.ConclusionPlatelet-rich plasma (PRP) to stimulate reparative osteogenesis is an inexpensive, easy to perform and effective alternative to the methods considered. The possibilities of application of this technology in traumatology and orthopedics require further research in order to create protocols for the use of PRPtherapy to stimulate the maturation of bone calluses. |
| Databáze: | OpenAIRE |
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