Meta-analysis and Clinical Evaluation of the Relationship Between FAPα Expression and Malignant Degree of Solid Tumors
| Autor: | Mo, Enpan, Tan, Qiutong, Cai, Shaohui, Shi, Mingjie, Xu, Jun |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| DOI: | 10.5281/zenodo.4818377 |
| Popis: | Background Aim This study aimed to identify the prognostic significance of Fibroblast activation protein α (FAPα) in solid tumor. Method A literature search was performed by using Pubmed, EMbase and CNKI for relevant articles published with the following key words “fibroblast activation protein” or “seprase”, “clinical” and “cancer” or “carcinoma”. Pooled effects with 95% confidence interval (CI) for outcomes (age, gender, positive ratio, histological differentiation, depth of tumor invasion, lymph node metastasis, clinical stage and overall survival) were calculated. Besides, immunohistochemical analysis was performed to evaluate FAPα positive ratio in normal, benign and malignant tumor tissues as well as in different degrees of differentiation, clinical stages and lymph node metastasis tissues. Results Finally, 28 articles with different types of solid tumors were included in the meta-analysis. Results revealed that solid tumors had a higher positive ratio of FAPα expression (OR: 39.51, P < 0.001), and FAPα overexpression also indicated higher degree of tumor depth invasion (OR: 2.82, P = 0.010), lymph node metastasis (OR: 2.52, P = 0.003), clinical stage (OR: 3.36, P = 0.003) and worse overall survival (HR: 2.03, P < 0.001). Results from immunohistochemistry demonstrated that FAPα expressed higher in malignant solid tumors than that in benign solid tumors (P = 0.022), and it significantly overexpress in lymph node metastasis tissues (P = 0.04). Conclusion Our findings indicate that FAPα expression is associated with worse prognosis in solid tumors and may be a promising prognosis predictor. This article aimed to identify the prognostic significance of Fibroblast activation protein α (FAPα) in solid tumor, we conducted by meta-analysis to found that solid tumors had a higher positive ratio of FAPα expression, which indicated higher degree of tumor depth invasion, lymph node metastasis, clinical stage and worse overall survival. The results from immunohistochemistry demonstrated that FAPα expressed higher in malignant solid tumors than that in benign solid tumors, and it significantly overexpress in lymph node metastasis tissues. Our findings indicate that FAPα expression is associated with worse prognosis in solid tumors and may be a promising biomarker in tumor diagnosis. |
| Databáze: | OpenAIRE |
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