Evidence for a critical role of entorhinal cortex at pre-exposure for latent inhibition disruption in rats
| Autor: | G. Di Scala, Karine Herbeaux, Alexandre Seillier, Monique Majchrzak, Y. Dieu, Bruno Will |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Conditioned emotional response Cognitive Neuroscience Emotions Models Neurological Conditioned response Neural Inhibition Tetrodotoxin Stimulus (physiology) Entorhinal cortex Sodium Channels Rats chemistry.chemical_compound Latent inhibition chemistry Conditioning Psychological Animals Entorhinal Cortex Conditioning Rats Long-Evans Neuroscience Sodium Channel Blockers |
| Zdroj: | Hippocampus. 17:220-226 |
| ISSN: | 1098-1063 1050-9631 |
| DOI: | 10.1002/hipo.20260 |
| Popis: | Latent inhibition (LI), that is the decrease in conditioned response induced by the repeated nonreinforced pre-exposures to the to-be-conditioned stimulus, is disrupted by entorhinal cortex (EC) lesions. The mechanism involved in this disruption is unknown, and in particular the experimental stage (pre-exposure or conditioning) at which the integrity of EC is necessary has to be determined. The purpose of this study was to address this issue by using reversible inactivation of the EC by local micro-infusion of tetrodotoxin (TTX). TTX was infused either before the pre-exposure phase, before the conditioning phase, or before both phases. LI was unaffected in rats that received TTX before conditioning or before both pre-exposure and conditioning. In contrast, LI was disrupted in rats that received TTX before pre-exposure only. These results are discussed in the framework of LI models. © 2007 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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