Copper-catalyzed three-component synthesis of aminonaphthoquinone-sulfonylamidine conjugates and in vitro evaluation of their antiproliferative activity

Autor:	Ahmed Kamal, T. D. Suja, K. V. L. Divya, Lakshma V. Naik, A. Ravi Kumar
Rok vydání:	2015
Předmět:	medicine.drug_class Stereochemistry Clinical Biochemistry Amidines Pharmaceutical Science Antineoplastic Agents 010402 general chemistry 01 natural sciences Biochemistry Catalysis Structure-Activity Relationship Cell Line Tumor Drug Discovery medicine Structure–activity relationship Humans Molecular Biology Cell Proliferation Sulfonyl chemistry.chemical_classification Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Cell growth Organic Chemistry Combinatorial chemistry In vitro 0104 chemical sciences Enzyme chemistry Docking (molecular) Molecular Medicine Drug Screening Assays Antitumor Topoisomerase inhibitor Copper Conjugate Naphthoquinones
Zdroj:	Bioorganicmedicinal chemistry letters. 26(8)
ISSN:	1464-3405
Popis:	A series of aminonaphthoquinone-sulfonylamidine conjugates were synthesized via a copper-catalyzed three-component reaction of N-propargyl aminonaphthoquinone, sulfonyl azides and various amines. Majority of the compounds exhibited promising antiproliferative potential when evaluated against a panel of four cancer cell lines. Docking experiments of representative compounds indicated that the conjugates can occupy the ATP-binding pocket of topoisomerase-II enzyme.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0d16f35eb0423883928f0da304c5a3 https://pubmed.ncbi.nlm.nih.gov/26948541 Zobrazit plný text záznamu Full Text from ScienceDirect