Effects of diltiazem and verapamil on ADP-induced rabbit platelet shape change and aggregation
| Autor: | Maziar Mohammad Akhavan, T. Samadian, Ahmad Reza Dehpour, Aziz Delfan, Farnoush Meysamee |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Platelet Aggregation Pharmacology Inhibitory postsynaptic potential Diltiazem Internal medicine medicine Animals Platelet skin and connective tissue diseases ED50 Lagomorpha biology Dose-Response Relationship Drug Chemistry Calcium channel biology.organism_classification Calcium Channel Blockers In vitro Adenosine Diphosphate Endocrinology Verapamil Female sense organs Rabbits medicine.drug |
| Zdroj: | General pharmacology. 26(6) |
| ISSN: | 0306-3623 |
| Popis: | 1. 1. The effects of diltiazem and verapamil (two structurally different calcium channel blockers) were examined on the rabbit platelets shape change and aggregation induced by adenosine-5′-diphosphate (ADP). 2. 2. ADP was a much more potent stimulator on inducing platelet shape change (ED50 = 1 × 10−7) than platelet aggregation (ED50 = 1.78 × 10−6). 3. 3. Both drugs similarly inhibited ADP-induced platelet shape change and aggregation at concentrations more than 300 μM. 4. 4. There were no significant differences in inhibitory effects of either diltiazem or verapamil on ADP-induced platelet shape change and aggregation. 5. 5. The inhibitory effects of diltiazem and verapamil on ADP-induced platelet shape change and aggregation at high concentrations may be due to their non specific properties. |
| Databáze: | OpenAIRE |
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