Potential role of marine species-derived bioactive agents in the management of SARS-CoV-2 infection
| Autor: | Hafiza Sidra Yaseen, Malik Saadullah, Chern E. Oon, Ikram Ullah Khan, Mahrukh, Syed Haroon Khalid, Muhammad Asif, Mohammad Saleem, Hafiz Muhammad Zubair, Ashwaq Hs Yehya, Pegah Moradi Khaniabadi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Drug Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) In silico media_common.quotation_subject Oceans and Seas Phytochemicals Anti-Inflammatory Agents Marine Biology Computational biology Review Microbiology Marine species Antiviral Agents Peptides Cyclic plitidepsin Alkaloids In vivo Polysaccharides Fingolimod Hydrochloride Depsipeptides Lectins medicine Humans fingolimod media_common anti-inflammatory Griffithsin biology griffithsin SARS-CoV-2 Phycocyanin COVID-19 Polyphenols Seaweed Fingolimod COVID-19 Drug Treatment Molecular Docking Simulation marine drugs biology.protein Plant Lectins Sesquiterpenes medicine.drug |
| Zdroj: | Future Microbiology |
| ISSN: | 1746-0921 1746-0913 |
| Popis: | COVID-19, caused by the SARS-CoV-2 outbreak, has resulted in a massive global health crisis. Bioactive molecules extracted or synthesized using starting material obtained from marine species, including griffithsin, plitidepsin and fingolimod are in clinical trials to evaluate their anti-SARS-CoV-2 and anti-HIV efficacies. The current review highlights the anti-SARS-CoV-2 potential of marine-derived phytochemicals explored using in silico, in vitro and in vivo models. The current literature suggests that these molecules have the potential to bind with various key drug targets of SARS-CoV-2. In addition, many of these agents have anti-inflammatory and immunomodulatory potentials and thus could play a role in the attenuation of COVID-19 complications. Overall, these agents may play a role in the management of COVID-19, but further preclinical and clinical studies are still required to establish their role in the mitigation of the current viral pandemic. Graphical abstract |
| Databáze: | OpenAIRE |
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