A case of acute promyelocytic leukemia with morphologic multilineage dysplastic changes
| Autor: | Toshiaki Kojitani, Keiko Nagata, Eiji Tatsumi, Keiko Numata, Katsuyasu Saigo, Mariko Takenokuchi, Akiharu Okamura, Setsuki Isono, Masafumi Takata, Akihiko Nishizawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Acute promyelocytic leukemia
acute promyelocytic leukemia dysplasia all-trans retinoic acid Pathology medicine.medical_specialty medicine.medical_treatment Case Report Typical Acute Promyelocytic Leukemia dysplasia immune system diseases hemic and lymphatic diseases Rare case Medicine neoplasms Cytopenia business.industry lcsh:RC633-647.5 Karyorrhexis Hematology lcsh:Diseases of the blood and blood-forming organs acute promyelocytic leukemia medicine.disease Pancytopenia Radiation therapy all-trans retinoic acid Dysplasia business |
| Zdroj: | Hematology Reports, Vol 5, Iss 1, Pp e5-e5 (2013) Hematology Reports |
| ISSN: | 2038-8330 2038-8322 |
| Popis: | Although reports of typical acute promyelocytic leukemia (APL) cases rarely mention dysplastic changes, this report concerns a rare case of APL with tri-lineage dysplastic changes resembling the characteristic features of myelodysplastic syndrome (MDS). The patient, a 77-year-old Japanese male, was diagnosed as having pancytopenia with hematologic morphological abnormalities comprising micromegakaryocytes, neutrophils with hypo-granulation and negative peroxidase activity, and erythroblasts containing nuclei with abnormalities such as karyorrhexis. Although there is one report of a case of transformation of de novo MDS into APL and several reports of cases of therapy-related MDS transformed into APL, our patient had no history of cytopenia or of either chemo or radiation therapy. Our case can thus be considered to constitute a rare case of APL with dysplastic morphology. |
| Databáze: | OpenAIRE |
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