17β-estradiol enhances memory duration in the main olfactory bulb in CD-1 mice
| Autor: | Laura C Fox, T Samuel Dillon, Christiane Linster, Crystal Han |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Olfactory system Behavior Animal Estradiol Estrogen receptor PHTPP Olfactory Bulb Article Olfactory bulb Mice Behavioral Neuroscience Odor Memory Odorants Animals Estrogen Receptor beta Learning Female Habituation Olfactory memory Habituation Psychophysiologic Psychology Neuroscience hormones hormone substitutes and hormone antagonists Estrogen receptor beta |
| Zdroj: | Behavioral Neuroscience. 127:923-931 |
| ISSN: | 1939-0084 0735-7044 |
| DOI: | 10.1037/a0034839 |
| Popis: | Rodents rely heavily on odor detection, discrimination, and memory to locate food, find mates, care for pups, and avoid predators. Estrogens have been shown to increase memory retention in rodents performing spatial memory and object placement tasks. Here we evaluate the extent to which 17β-estradiol modulates memory formation and duration in the olfactory system. Adult CD-1 mice were gonadectomized (GDx) and given either systemic 17β-estradiol replacement, local 17β-estradiol in the main olfactory bulb, or no replacement. Before performing the behavioral task the mice were given saline or PHTPP (an estrogen receptor β (ER-β) antagonist) via bilateral infusion into the main olfactory bulb. As the beta-type estrogen receptor (ER-β) is more abundant than the alpha-type estrogen receptor in the murine main olfactory bulb, the current study focuses on 17β-estradiol and its interactions with ERβ. Habituation, a simple non-associative learning task in which an animal is exposed to the same odor over successive presentations, was used to evaluate the animals' ability to detect odors and form an olfactory memory. To evaluate memory duration, we added a final trial of inter-trial interval time (30 or 60 minutes) in which we presented the habituated odor. Neither surgical nor drug manipulation affected the ability of mice to detect or habituate to an odor. After habituation, GDx 17β-estradiol treated mice retained memory of an odor for 30 minutes while non-estradiol treated, 17β-estradiol + ERβ antagonist (PHTPP), and untreated male mice did not remember an odor 30 minutes post habituation. The results show that both systemic and local bulbar infusions of 17β-estradiol enhance odor memory duration in mice. |
| Databáze: | OpenAIRE |
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