Probiotics ameliorates LPS induced neuroinflammation injury on Aβ 1-42, APP, γ-β secretase and BDNF levels in maternal gut microbiota and fetal neurodevelopment processes
| Autor: | Fatih Kar, Ceyhan Hacioglu, Ezgi Kar, Dilek Burukoglu Donmez, Güngör Kanbak |
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| Rok vydání: | 2021 |
| Předmět: |
Lipopolysaccharides
Brain-Derived Neurotrophic Factor Probiotics Biochemistry Actins Gastrointestinal Microbiome Rats Cellular and Molecular Neuroscience Pregnancy Neuroinflammatory Diseases Animals Female Neurology (clinical) RNA Messenger Amyloid Precursor Protein Secretases Rats Wistar Leukocyte L1 Antigen Complex |
| Zdroj: | Metabolic brain disease. 37(5) |
| ISSN: | 1573-7365 |
| Popis: | The gut microbiota influences brain development and functioning through the gut-brain axis. This is first study regulate maternal gut microbiota and fetal neurodevelopment processes by using probiotics such as Bifidobacterium bifidum (BIF) and Lactobacillus salivarius (LAC) in the prenatal period. In this study, Wistar Albino female rats were divided into five groups; Control, lipopolysaccharide (LPS, 100 µg/kg), LPS + LAC, LPS + BIF and LPS + LAC + BIF (4 × 10 |
| Databáze: | OpenAIRE |
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