Squamous cell carcinoma of the gingivobuccal complex: predictors of locoregional failure in stage III-IV cancers
| Autor: | Mandar S. Deshpande, Rohan R. Walvekar, Devendra Chaukar, Prathamesh S. Pai, Anagha C. Kakade, Pankaj Chaturvedi, Anil K. D'Cruz |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty medicine.medical_treatment Disease-Free Survival Metastasis Cohort Studies Young Adult Median follow-up Internal medicine medicine Humans Basal cell carcinoma Stage (cooking) Aged Neoplasm Staging Retrospective Studies Aged 80 and over Univariate analysis Analysis of Variance Gingival Neoplasms business.industry Cancer Neck dissection Middle Aged medicine.disease Epidermoid carcinoma Lymphatic Metastasis Carcinoma Squamous Cell Female Mouth Neoplasms Oral Surgery Neoplasm Recurrence Local business |
| Zdroj: | Oral oncology. 45(2) |
| ISSN: | 1879-0593 |
| Popis: | The purpose of our study was to analyze the indicators of loco-regional failure in a large cohort of patients with gingivobuccal complex tumors treated at a single institution. A retrospective review of 2275 patients diagnosed with tumors of the gingivobuccal complex was conducted from January 1997 to December 1999; 642 patients who fulfilled our inclusion criteria were analyzed. A univariate analysis, multivariate analysis, and disease-free survival are reported. During a median follow up of 2.51 years, there were 228 (35.5%) recurrences with a median post-recurrence survival of 2.7 months. The incidence of occult neck metastasis was 29%. The 2- and 5-year DFS rates were 63.8% and 53.3%, respectively. On multivariate analysis, tumor depth and metastatic lymphadenopathy were found to be independent prognostic factors for disease-free survival. Advanced gingivobuccal cancers fail loco-regionally. Cervical metastasis and tumor depth influence disease-free survival. Elective neck dissection due to a high incidence of occult neck disease is recommended. |
| Databáze: | OpenAIRE |
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