Role of Iron Chelation and Protease Inhibition of Natural Products on COVID-19 Infection
| Autor: | Giuseppe Carota, Federica Panarello, Giovanni Li Volti, Daniele Tibullo, Simone Ronsisvalle, Anna Nicolosi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Coronavirus disease 2019 (COVID-19)
natural products Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) medicine.medical_treatment viruses SARS-Cov-2 Review Virus Iron chelation 03 medical and health sciences 0302 clinical medicine Docking (dog) COVID‐19 Pulmonary fibrosis medicine 030304 developmental biology Infectivity 0303 health sciences iron chelation Protease business.industry COVID-19 General Medicine medicine.disease SARS‐Cov‐2 protease inhibition 030220 oncology & carcinogenesis Immunology Medicine business |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 2306, p 2306 (2021) |
| ISSN: | 2077-0383 |
| Popis: | Although the epidemic caused by SARS-CoV-2 callings for international attention to develop new effective therapeutics, no specific protocol is yet available, leaving patients to rely on general and supportive therapies. A range of respiratory diseases, including pulmonary fibrosis, have been associated with higher iron levels that may promote the course of viral infection. Recent studies have demonstrated that some natural components could act as the first barrier against viral injury by affecting iron metabolism. Moreover, a few recent studies have proposed the combination of protease inhibitors for therapeutic use against SARS-CoV-2 infection, highlighting the role of viral protease in virus infectivity. In this regard, this review focuses on the analysis, through literature and docking studies, of a number of natural products able to counteract SARS-CoV-2 infection, acting both as iron chelators and protease inhibitors. |
| Databáze: | OpenAIRE |
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