Age-related changes in primary somatosensory cortex of rats: evidence for parallel degenerative and plastic-adaptive processes
| Autor: | Thomas Berkefeld, Ben Godde, Marianne David-Jürgens, Hubert R. Dinse |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Aging
Cognitive Neuroscience Action Potentials Sensory system Walking Tarsus Animal Somatosensory system Brain mapping Behavioral Neuroscience Carpus Animal Cognition Neuroplasticity Reaction Time Animals skin and connective tissue diseases Neurons Brain Mapping Environmental enrichment Neuronal Plasticity Sensory stimulation therapy Behavior Animal Somatosensory Cortex Environment Controlled Rats Electrophysiology Neuropsychology and Physiological Psychology Receptive field Cerebrovascular Circulation Sensation Disorders Calcium sense organs Cognition Disorders Psychology Neuroscience |
| Zdroj: | Neuroscience & Biobehavioral Reviews. 26:743-752 |
| ISSN: | 0149-7634 |
| DOI: | 10.1016/s0149-7634(02)00061-1 |
| Popis: | Aged rats show a characteristic decline of the sensorimotor state, most strikingly expressed in an impairment of the hindlimbs leading to significantly reduced sensory stimulation on the hindpaw. We review recent studies using optical imaging and electrophysiological recordings to investigate the effects of aging on somatosensory cortex and to identify age-related changes in terms of degeneration or plastic adaptation. For the cortical hindpaw representation, reduction of map size, receptive field enlargement and reduced response strength were described. None of these changes were reported in the forepaw representation in the same individual, however, in both the fore-and hindpaw representations response latencies and cerebral blood flow were affected. Changes of latencies and blood flow are best explained by degeneration, but the regional and specific changes of maps, receptive fields and response strength by plastic phenomena arising from the reduced sensory inputs. While the degenerative changes are not modifiable by enriched environmental conditions or application of Ca 2þ blocker, the plastic changes were fully reversible under these conditions. We discuss the implications of these findings for cognitive functions at old age and possible treatments of age-related changes in human subjects. q 2002 Elsevier Science Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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