Familial hypercholesterolemia in very young myocardial infarction
| Autor: | Na-Qiong Wu, Xiao-Lin Li, Sha Li, Ping Qing, Jian-Jun Li, Yuan-Lin Guo, Xiong-Yi Gao, Yan Zhang, Cheng-Gang Zhu, Geng Liu, Chuan-Jue Cui, Hui-Wen Zhang, Qian Dong, Jing Sun, Rui-Xia Xu, Xi Zhao, Ying Gao, Di Sun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty China Myocardial Infarction lcsh:Medicine Familial hypercholesterolemia Comorbidity 030204 cardiovascular system & hematology Angina Hyperlipoproteinemia Type II 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Prevalence Humans 030212 general & internal medicine Myocardial infarction Angina Unstable lcsh:Science Stroke Proportional Hazards Models Multidisciplinary Unstable angina business.industry Proportional hazards model Anticholesteremic Agents Hazard ratio lcsh:R Age Factors medicine.disease Lipid Metabolism Cardiology Female lcsh:Q business |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Familial hypercholesterolemia (FH) is one of the most common causes of premature myocardial infarction (MI). However, The patterns of FH remained unrecognized in clinical care, especially in very young patients (VYPs, ≤35 years) with MI. The present study enrolled a total of 1,093 VYPs (≤35 years) presenting a first MI. Clinical diagnosis of FH was made using Dutch Lipid Clinic Network criteria. Coronary severity was assessed by Gensini score (GS). Patients were followed for a median of 40-months with cardiac death, stroke, MI, post-discharge revascularization or unstable angina as primary endpoints. The detected rates of definite/probable FH were 6.5%. The prevalence reached up to 10.3% in patients ≤25 years. The FH had similar levels of comorbidities but was younger, more likely to be very high risk (VHR) and had higher GS (p |
| Databáze: | OpenAIRE |
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