Effects of Liposomal Simvastatin Nanoparticles on Vascular Endothelial Function and Arterial Smooth Muscle Cell Apoptosis in Rats with Arteriosclerotic Occlusive Disease of Lower Limb via P38 Mitogen-Activated Protein Kinase Nuclear Factor Kappa-B Pathway
| Autor: | Wei Lu, Jiawen Wu, Guobing Cheng, Senyan Wu, Xiaoyang Li, Sheng Liao, Qiang Hu, Shuiwei Qiu |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
Simvastatin Materials science media_common.quotation_subject Myocytes Smooth Muscle Biomedical Engineering Blood lipids Apoptosis Bioengineering 02 engineering and technology Pharmacology p38 Mitogen-Activated Protein Kinases Rats Sprague-Dawley 03 medical and health sciences medicine.artery Hyperlipidemia polycyclic compounds medicine Animals General Materials Science cardiovascular diseases 030304 developmental biology media_common 0303 health sciences Liposome Aorta NF-kappa B nutritional and metabolic diseases General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics medicine.disease In vitro Rats Lower Extremity Nanoparticles lipids (amino acids peptides and proteins) Nanocarriers 0210 nano-technology medicine.drug |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 21:1169-1175 |
| ISSN: | 1533-4880 |
| Popis: | This article prepared a simvastatin-NLCs for the treatment of arteriosclerotic occlusive disease of lower limbs. Taking the size distribution, polydispersity coefficient, encapsulation efficiency and drug loading of simvastatin-NLCs as evaluation indicators, various prescription factors of simvastatin-NLCs were investigated. The in vitro release behavior and stability of simvastatin-NLCs were also investigated. A hyperlipidemia rat model was established using high-fat diets. SD rats fed ordinary diet were set as normal control groups. 20 rats, 20 in the simvastatin group and 20 in the simvastatin nanocarrier group. After 5 weeks of drug intervention, the rats were sacrificed and the aorta was taken to determine the smooth muscle cell apoptosis rate. Studies have shown that simvastatin nanocarriers can more effectively reduce blood lipids in hyperlipidemia rats, increase the rate of smooth muscle cell apoptosis in hyperlipidemia rats, and delay the onset of atherosclerosis. |
| Databáze: | OpenAIRE |
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