2020 international consensus on ANCA testing beyond systemic vasculitis
| Autor: | Judith Savige, Alan D. Salama, Maria José Rego Sousa, Pavel Novikov, Athanasios G. Tzioufas, Sergey Moiseev, Yehuda Shoenfeld, Elena Csernok, Xavier Bossuyt, Yoshihiro Arimura, Marc Ferrante, Marvin J. Fritzler, Benjamin Terrier, Luis Felipe Flores-Suárez, Jan Willem Cohen Tervaert, Mark A. Little, Ulrich Specks, Mårten Segelmark, J. Charles Jennette, Dimitrios P. Bogdanos, David Jayne, Charles D. Pusey, Stephen P. McAdoo, Jan Damoiseaux, Ming Hui Zhao, Pietro Invernizzi, Antonella Radice, Renato Alberto Sinico, Severine Vermeire |
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| Přispěvatelé: | Moiseev, S, Tervaert, J, Arimura, Y, Bogdanos, D, Csernok, E, Damoiseaux, J, Ferrante, M, Flores-Suárez, L, Fritzler, M, Invernizzi, P, Jayne, D, Jennette, J, Little, M, Mcadoo, S, Novikov, P, Pusey, C, Radice, A, Salama, A, Savige, J, Segelmark, M, Shoenfeld, Y, Sinico, R, Sousa, M, Specks, U, Terrier, B, Tzioufas, A, Vermeire, S, Zhao, M, Bossuyt, X |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
ANTI-SACCHAROMYCES-CEREVISIAE MICROSCOPIC POLYANGIITIS medicine.medical_specialty Consensus BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN Myeloblastin Immunology ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Autoimmune hepatitis urologic and male genital diseases PRIMARY SJOGRENS-SYNDROME Inflammatory bowel disease Antibodies Antineutrophil Cytoplasmic 03 medical and health sciences 0302 clinical medicine immune system diseases Immunology and Allergy Medicine Humans cardiovascular diseases CLINICAL-SIGNIFICANCE skin and connective tissue diseases Idiopathic interstitial pneumonia Anti-neutrophil cytoplasmic antibody Peroxidase 030203 arthritis & rheumatology anti-neutrophil cytoplasm antibodies (ANCA) connective tissue diseases idiopathic interstitial pneumonia autoimmune liver diseases inflammatory bowel diseases anti-glomerular basement membrane (GBM) disease infections malignancy business.industry TUBULIN ISOTYPE 5 Granulomatosis with Polyangiitis PRIMARY SCLEROSING CHOLANGITIS medicine.disease AUTOIMMUNE LIVER DISORDERS Dermatology RHEUMATOID-ARTHRITIS respiratory tract diseases Hepatitis Autoimmune 030104 developmental biology business Granulomatosis with polyangiitis Vasculitis Microscopic polyangiitis INFLAMMATORY-BOWEL-DISEASE Systemic vasculitis |
| Popis: | This document follows up on a 2017 revised international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic polyangiitis and focuses on the clinical and diagnostic value of ANCA detection in patients with connective tissue diseases, idiopathic interstitial pneumonia, autoimmune liver diseases, inflammatory bowel diseases, anti-glomerular basement membrane (GBM) disease, infections, malignancy, and during drug treatment. Current evidence suggests that in certain settings beyond systemic vasculitis, ANCA may have clinical, pathogenic and/or diagnostic relevance. Antigen-specific ANCA targeting proteinase-3 and myeloperoxidase should be tested by solid phase immunoassays in any patient with clinical features suggesting ANCA-associated vasculitis and in all patients with anti-GBM disease, idiopathic interstitial pneumonia, and infective endocarditis associated with nephritis, whereas in patients with other aforementioned disorders routine ANCA testing is not recommended. Among patients with autoimmune liver diseases or inflammatory bowel diseases, ANCA testing may be justified in patients with suspected autoimmune hepatitis type 1 who do not have conventional autoantibodies or in case of diagnostic uncertainty to discriminate ulcerative colitis from Crohn's disease. In these cases, ANCA should be tested by indirect immunofluorescence as the target antigens are not yet well characterized. Many questions concerning the optimal use of ANCA testing in patients without ANCA-associated vasculitis remain to be answered. |
| Databáze: | OpenAIRE |
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