Synergistic Effect of Diacylglycerol and Vitamin D in Ameliorating Dextran Sodium Sulfate-Induced Colitis in Rats
| Autor: | Mingai Zhang, Baowei Wang, Ge Wenhua, Xie Yu'e, Xu Huixin, Liu Yanan, Fan Wenlei, Kong Min |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Antioxidant medicine.medical_treatment Sodium chemistry.chemical_element Pharmacology Biochemistry Antioxidants Diglycerides Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Intestinal mucosa medicine Vitamin D and neurology Animals Colitis Vitamin D Diacylglycerol kinase 030109 nutrition & dietetics Organic Chemistry Body Weight Dextran Sulfate Drug Synergism Cell Biology medicine.disease Enzymes Gastrointestinal Microbiome PPAR gamma Disease Models Animal 030104 developmental biology Cytokine Dextran Ducks chemistry Gene Expression Regulation Intestinal Absorption Cytokines Drug Therapy Combination Spleen |
| Zdroj: | LipidsReferences. 55(6) |
| ISSN: | 1558-9307 |
| Popis: | Vitamin D (VD) has the function of antibacteria and protect intestinal mucosa. Diacylglycerol has the property of dissolving VD, anti-bacterial, and antioxidant effects. The purpose of this study was to explore the potentially synergistic effects of diacylglycerol and VD in ameliorating dextran sodium sulfate-induced colitis in rats. A 2 × 3 factorial design was used in this experiment, consisting of two levels of VD (2.5 and 5 μg/day) crossed with three levels of duck oil diacylglycerol (0.5, 1, and 2 mL/day). The experiment lasted for 2 weeks. Compared with the colitis group, the physiological indexes were altered in colitis rats treated with diacylglycerol and VD, the concentrations of the pro-inflammatory indices were significantly reduced, the antioxidant enzyme activities were significantly increased, the diversity of caecal microflora was significantly increased. Besides, the expression of PPARγ was up-regulated while the expression of NF-κBp65 was downregulated. The changes of all those measures were toward those in the Healthy Control, and the mostly appropriate combination was 1 mL/day of diacylglycerol plus 2.5 μg/day VD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text