NMDA receptor modulation by dextromethorphan and acute stress selectively alters electroencephalographic indicators of partial report processing
| Autor: | Lisa J. Weckesser, Sören Enge, Philipp Riedel, Robert Miller, Clemens Kirschbaum |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Hydrocortisone Mismatch negativity Neuropsychological Tests Electroencephalography Neurotransmission Placebo Dextromethorphan Receptors N-Methyl-D-Aspartate 03 medical and health sciences Glutamatergic 0302 clinical medicine Double-Blind Method Internal medicine medicine Humans Pharmacology (medical) Saliva Biological Psychiatry Pharmacology medicine.diagnostic_test Antagonist Brain Affect Psychiatry and Mental health 030104 developmental biology Endocrinology Neurology Anesthesia Auditory Perception Visual Perception Evoked Potentials Visual NMDA receptor Neurology (clinical) Psychology Excitatory Amino Acid Antagonists Stress Psychological 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Neuropsychopharmacology. 27:1042-1053 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/j.euroneuro.2017.07.003 |
| Popis: | Proceeding from a biophysical network model, the present study hypothesized that glutamatergic neurotransmission across the NMDA receptor (NMDAR) plays a key role in visual perception and its modulation by acute stress. To investigate these hypotheses, behavioral and electroencephalographic (EEG) indicators of partial report task processing were assessed in twenty-four healthy young men who randomly received a non-competitive NMDAR antagonist (0.8 mg/kg dextromethorphan, DXM) or a placebo, and concurrently accomplished a stress-induction (MAST) or control protocol in three consecutive sessions. Saliva samples served to quantify cortisol responses to the MAST, whereas a passive auditory oddball paradigm was implemented to verify the impact of DXM on the EEG-derived mismatch negativity component (MMN). DXM administration significantly increased MMN amplitudes but not salivary cortisol concentrations. By contrast, concurrent MAST exposure significantly reduced MMN latencies but also increased cortisol concentrations. With regard to EEG indicators, DXM administration reduced visually "evoked" (30Hz to 50Hz) and "induced" occipital gamma-band activity (70Hz to 100Hz), which was partly compensated by additional MAST exposure. However, neither the interventions nor EEG activity were significantly associated with behavioral partial report sensitivities. In summary, the present data suggest that glutamatergic neurotransmission across the NMDAR is only one among many determinants of intact visual perception. Accordingly, therapeutic doses of DXM and their inhibitory modulation by stress probably yield more pronounced electroencephalographic as compared with behavioural effects. |
| Databáze: | OpenAIRE |
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