EPA in the Prevention of Restenosis Post PTCA
| Autor: | Thomas G. Plavac, Gregory R. Boxberger, Dan A. Francisco, Brenda Gonzales, Joseph P. Galichia, Larry R. Poliner, Roger W. Roberts, Mark Howard Bowles, Demo Klonis |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Coronary Disease Coronary balloon angioplasty Constriction Pathologic 030204 cardiovascular system & hematology Coronary Angiography Scintigraphy 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Restenosis Internal medicine medicine Humans In patient 030212 general & internal medicine Severe stenosis Angioplasty Balloon Coronary Thrombus Chemotherapy medicine.diagnostic_test business.industry Anticoagulants medicine.disease Coronary Vessels Surgery Eicosapentaenoic Acid Exercise Test Cardiology Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Angiology. 42:187-194 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/000331979104200302 |
| Popis: | The effect of fish oil on restenosis was evaluated in patients undergoing coronary balloon angioplasty. In addition to routine pharmacotherapy, subjects were given 2.8 g of eicosapentanoic acid (EPA) daily. Treatment was started within twenty-four hours after successful percutaneous transluminal coronary angioplasty (PTCA). After six months of therapy, participants were subjected to coronary arteriography, exercise scintigraphy, exercise electrocardiography, or clinical evaluation. Follow-up evaluation involved 97 coronary lesions in 85 patients. Partial or significant restenosis occurred in 36.5% of patients and 33 % of vessels. The presence of severe stenosis before PTCA, dissection, thrombus, multilesion PTCA, and template bleeding time values were not correlated with restenosis. Dilation of the left anterior descending (LAD) and a residual stenosis≥ 35 % were associated with restenosis. Approximately 20% of the patients related difficulty in taking the fish oil. Furthermore, these results show no advantage over expected restenosis rates. |
| Databáze: | OpenAIRE |
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