A non-major histocompatibility locus determines tissue specificity in the pathogenic process underlying synovial proliferation in a mouse arthropathy model
| Autor: | Fumiko Date, Masao Ono, Mingcai Zhang, Shiro Mori, Hiroshi Furukawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Mice Inbred MRL lpr Pathology medicine.medical_specialty Concise Report Genotype Ratón Immunology Locus (genetics) Breeding Biology General Biochemistry Genetics and Molecular Biology Pathogenesis Mice Rheumatology Rheumatic Diseases medicine Ankylosis Animals Immunology and Allergy Genetic Predisposition to Disease Allele skin and connective tissue diseases Cell Proliferation Autoimmune disease Mice Inbred C3H Histocytochemistry Synovial Membrane medicine.disease Chromosomes Mammalian Connective tissue disease Mice Mutant Strains Disease Models Animal medicine.anatomical_structure Female Joint Diseases Synovial membrane Microsatellite Repeats |
| Zdroj: | Annals of the Rheumatic Diseases. 66(2):242-245 |
| ISSN: | 0003-4967 |
| Popis: | Background: The incidence and characteristics of spontaneous ankylosis in the ankle of specific F 1 mice descended from two Fas -deficient strains were reported. Here the coincidence of synovial proliferation and ankylosis in the descendent F 2 mice is reported. Aim: To clarify whether the two distinct manifestations are genetically different. Methods: An arthropathic group of mice (MCF 2 ) were bred by intercrossing MRL/Mp. Fas lpr - sap – /sap – and C3H/He. Fas lpr mice. All mice were killed by bleeding under anaesthesia when they were 6 months old. Pathological grades for synovial proliferation were determined by microscopical examination. To obtain a linkage locus, the whole genome of male MCF 2 mice was scanned by using 73 microsatellite markers. Results: Synovial proliferation was equally observed in male and female MCF 2 mice. No correlation was observed between the grades of synovial proliferation and the ankylosis occurring in the MCF 2 mice. A suggestive susceptibility locus was shown in the middle of chromosome 11. This locus was an MRL allele with a recessive inheritance mode. Conclusion: The pathogenic mechanisms of synovial proliferation and ankylosis are genetically different. The present locus is overlapped with some loci associated with rheumatoid arthritis and with others associated with experimental arthritides. |
| Databáze: | OpenAIRE |
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