Neuro-Retina Might Reflect Alzheimer's Disease Stage
| Autor: | Monica Falautano, Su Chun Huang, Letizia Leocani, Roberto Santangelo, Giuseppe Magnani, Giancarlo Comi, Maria Paola Bernasconi |
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| Přispěvatelé: | Santangelo, R., Huang, S. -C., Bernasconi, M. P., Falautano, M., Comi, G., Magnani, G., Leocani, L. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
inner plexiform layer medicine.medical_specialty genetic structures neuro-retina Nerve fiber layer Retina 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Atrophy Cerebrospinal fluid mild cognitive impairment Alzheimer Disease Ophthalmology medicine Humans Neuropsychological assessment Ganglion cell layer ganglion cell layer Aged Aged 80 and over optical coherence tomography medicine.diagnostic_test business.industry General Neuroscience retinal nerve fiber layer Retinal General Medicine Middle Aged Alzheimer's disease medicine.disease Inner plexiform layer eye diseases Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Cross-Sectional Studies chemistry 030221 ophthalmology & optometry Female sense organs Geriatrics and Gerontology business 030217 neurology & neurosurgery Biomarkers Tomography Optical Coherence Retinal Neurons |
| Popis: | Background: Alzheimer’s disease (AD) pathological hallmarks were found in retinas of AD patients. Several studies showed a significant reduction of neuro-retina thickness measured through optical coherence tomography (OCT) in AD patients, but possible correlations between retina morphology, cognition, and cerebrospinal fluid (CSF) AD biomarkers (Aβ42, t-tau, and p-tau) have been poorly investigated so far. Objective: In the present cross-sectional study, we measured the thickness of neuro-retinal layers through OCT searching for possible correlations with patients’ cognitive performances and CSF AD biomarkers. Methods: 137 consecutive subjects [43 with AD, 37 with mild cognitive impairment (MCI), and 57 healthy controls (HC)], received an OCT scan acquisition to measure the peripapillary retinal nerve fiber layer (RNFL) thickness. In a subsample of 21 AD, 18 MCI, and 18 HC, the macular volume of ganglion cell layer (GCL), inner plexiform layer (IPL), and inner nuclear layer was computed. A comprehensive neuropsychological assessment and CSF AD biomarkers’ concentrations were available in AD and MCI patients. Results: Peripapillary RNFL, global, and in superior quadrant was significantly thinner in AD and MCI patients when compared to HC, while macular GCL volume was significantly reduced only in AD. RNFL thickness in nasal and inferior quadrants was correlated with single CSF AD biomarker concentrations, but no differences were found in retina morphology depending on the presence of a CSF profile typical for AD. Memory performances were positively associated with GCL and IPL volume. Conclusion: Our findings might propose OCT as a reliable and easy to handle tool able to detect neuro-retinal atrophy in AD in relation with cognitive performances. |
| Databáze: | OpenAIRE |
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