Spontaneous detachment of Streptococcus mutans biofilm by synergistic effect between zwitterion and sugar alcohol
| Autor: | Sang-Hun Song, Jong Hyun Lim, Sang-Min Lee, Hyunsub Park, Jeong Rae Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Science 030106 microbiology Erythritol Article Streptococcus mutans 03 medical and health sciences chemistry.chemical_compound Betaine Sugar Alcohols Sugar alcohol Sugar chemistry.chemical_classification Multidisciplinary biology Cationic polymerization Biofilm biochemical phenomena metabolism and nutrition biology.organism_classification Combinatorial chemistry Anti-Bacterial Agents chemistry Biochemistry Zwitterion Biofilms Medicine |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
| ISSN: | 2045-2322 |
| Popis: | A biofilm, a community of microorganisms, is highly resistant to antibiotics, resulting in massive losses in various areas. We herein present a strategy to remove Streptococcus mutans biofilms through a spontaneous exfoliation by the synergistic effect between zwitterion and sugar alcohols. It is assumed that the anionic site of zwitterion can be coupled with sugar alcohols and the cationic site remains in the state of lacking electrons. The cationic site allows the complexes to be delivered to negatively charged exopolysaccharides of biofilms. This strategy facilitates a significant increase in the ability of sugar alcohols to disperse aggregated exopolysaccharides. In this work, it was demonstrated that the mixture of betaine and erythritol existed as a complex in water and that the complex induced a spontaneous detachment of biofilms from the surface to which the biofilms had been adhered. This detachment resulted from a reduction in adhesive forces of the biofilms due to an increase in solubility of bacterial exopolysaccharides. The effects triggered by the formation of complex between zwitterion and sugar alcohol provide a simple and safe way to remove biofilms without antibiotics and physical forces. |
| Databáze: | OpenAIRE |
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