Propentofylline after focal cortical lesion in the rat: impact on functional recovery and basic fibroblast growth factor expression
| Autor: | Kimberley A. Buytaert-Hoefen, Theresa D. Hernandez, Uriah T. Walsh, Lisa A. Kreber, Chris Brannigan, Courtney J Millar |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Basic fibroblast growth factor Central nervous system Striatum Propentofylline Lesion chemistry.chemical_compound Cortex (anatomy) Internal medicine medicine Animals Rats Long-Evans Cerebral Cortex Adenosine transport business.industry General Neuroscience Recovery of Function Rats medicine.anatomical_structure Endocrinology Neuroprotective Agents chemistry Cerebral cortex Astrocytes Brain Injuries Xanthines Fibroblast Growth Factor 2 medicine.symptom business Neuroscience |
| Zdroj: | Neuroscience letters. 331(3) |
| ISSN: | 0304-3940 |
| Popis: | The effects of propentofylline, a xanthine derivative and adenosine transport inhibitor, were evaluated following anteromedial cortex lesion in the rat. Propentofylline (2×/10 mg/kg, intraperitoneally) was administered for 7 days post-insult and basic fibroblast growth factor (bFGF) immunoreactivity measured at designated time points in the peri-lesional cortex and ipsilateral dorsal striatum. The spatiotemporal pattern of bFGF expression was then compared to functional recovery patterns. Propentofylline-treated animals displayed increased bFGF expression in the peri-lesional cortex which may have contributed to the observed early facilitation of functional recovery. Drug administration did not, however, produce a change in bFGF expression in the ipsilateral dorsal striatum compared to saline-treated animals. These findings taken together with other positive findings regarding propentofylline, support the drug's therapeutic potential. |
| Databáze: | OpenAIRE |
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