Lymphocyte subset analysis in QuantiFERON-TB Gold Plus and T-Spot.TB for latent tuberculosis infection in rheumatoid arthritis
| Autor: | Mizue Tsuyuzaki, Ryutaro Matsumura, Kiminori Suzuki, Hidetoshi Igari, Satoru Ishikawa, Hidekazu Futami, Yoshihiro Oya, Takuya Nakazawa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Microbiology (medical) Cross-sectional study Cell Count CD8-Positive T-Lymphocytes Arthritis Rheumatoid Mycobacterium tuberculosis 03 medical and health sciences 0302 clinical medicine Immune system Latent Tuberculosis T-Lymphocyte Subsets medicine Humans Pharmacology (medical) 030212 general & internal medicine T-SPOT.TB Aged Aged 80 and over Antigens Bacterial Latent tuberculosis biology business.industry Middle Aged bacterial infections and mycoses medicine.disease biology.organism_classification Cross-Sectional Studies Logistic Models Infectious Diseases 030228 respiratory system Rheumatoid arthritis Immunology Female business Immunosuppressive Agents Interferon-gamma Release Tests CD8 Lymphocyte subsets |
| Zdroj: | Journal of Infection and Chemotherapy. 24:110-116 |
| ISSN: | 1341-321X |
| Popis: | Rheumatoid arthritis (RA) is an immune mediated inflammatory disorder, and immune suppressive drugs are prescribed. RA patients receiving treatments are in a kind of immunosuppressive condition that presents increased risk of developing active tuberculosis. Accurate diagnosis of latent tuberculosis infection (LTBI) is recommended for RA. QuantiFERON®-TB Gold Plus (QFT-Plus), a novel IGRA, has two tubes (TB1 and TB2). TB2 is designed to elicit both CD4 and CD8 T-cell responses, with expected increased sensitivity. We conducted a cross-sectional study to compare two IGRAs, QFT-Plus and T-SPOT®.TB (TSPOT), in RA. One hundred fifty-two RA patients (median age: 66.5 yrs) were enrolled. QFT-Plus and TSPOT were concurrently conducted. Lymphocyte subsets (CD4 T-cell and CD8 T-cell) were also measured. The positivity rates of QFT-Plus and TSPOT were 9.7% and 4.5%, respectively, with the difference being significant (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect