| Autor: |
Niall M. Killeen, Teyrnon C. Jones, Nicholas C. O. Tomkinson, Adrian Hall, Paul H. Taylor, Kerri L. Jones, Cory S. Beshara, Robert J. Jenkins, Stephen P. Thomas |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Organic letters. 7(25) |
| ISSN: |
1523-7060 |
| Popis: |
[chemical reaction: see text]. A simple, one-pot method for the alpha-acyloxylation of carbonyl compounds that proceeds at room temperature in the presence of both moisture and air has been developed. Treatment of a variety of aldehydes and both cyclic and acyclic ketones with N-methyl-O-benzoylhydroxylamine hydrochloride provides the alpha-functionalized product in 69-92% isolated yield. The transformation is tolerant of a wide range of functional groups and, significantly, is regiospecific in the discrimination of secondary over primary centers in the case of nonsymmetrical substrates. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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