Correlation between miR-148 Expression in Vitreous and Severity of Rhegmatogenous Retinal Detachment
| Autor: | Toshiyuki Matsuura, Shunsuke Yasuda, Shinji Ueno, Norie Nonobe, Shiang-Jyi Hwang, Yasuki Ito, Keiko Kataoka, Yosuke Nagasaka, Taichi Tsunekawa, Hiroko Terasaki, Hiroki Kaneko, Hideyuki Shimizu, Akio Oishi, Fuxiang Ye, Takeshi Iwase, Kei Takayama, Ayana Suzumura |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Visual acuity medicine.medical_treatment Visual Acuity lcsh:Medicine Vitrectomy chemistry.chemical_compound 0302 clinical medicine Risk Factors medicine.diagnostic_test Retinal detachment General Medicine Middle Aged medicine.anatomical_structure Female medicine.symptom Research Article Adult medicine.medical_specialty Retinal breaks Epithelial-Mesenchymal Transition Article Subject Fundus Oculi Real-Time Polymerase Chain Reaction General Biochemistry Genetics and Molecular Biology Ophthalmoscopy 03 medical and health sciences Ophthalmology medicine Humans Aged Retinal pigment epithelium General Immunology and Microbiology business.industry lcsh:R Retinal Detachment Retinal medicine.disease Retinal Perforations eye diseases body regions Vitreous Body MicroRNAs 030104 developmental biology chemistry Gene Expression Regulation Vitreous hemorrhage 030221 ophthalmology & optometry sense organs business |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2017 (2017) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Purpose.We had earlier reported positive hsa-miR-148a-3p expression in eyes with rhegmatogenous retinal detachment (RRD) and its involvement in the epithelial-mesenchymal transition of retinal pigment epithelium in vitro. Here we investigated the association of hsa-miR-148a-3p expression levels in the vitreous fluid of patients with RRD with severity of RRD.Methods.The hsa-miR-148a-3p expression levels in the vitreous fluid, range (degree) of retinal detachment (RD), and pixels of retinal break were measured in 27 eyes with RRD. The association of hsa-miR-148a-3p expression levels with other factors was evaluated by multiple regression analysis.Results.The hsa-miR-148a-3p expression levels, time from onset of RRD to vitrectomy, range of RD, and pixels of retinal breaks were23.68±43.00,12.07±15.36days,155.85±86.67degrees, and37000±67100pixels, respectively. Five eyes with RRD had vitreous hemorrhage preoperatively. The hsa-miR-148a-3p expression levels were significantly associated with pixels of retinal breaks (β=0.699) and the time from onset of RRD to vitrectomy (β=0.358) but not with the range of RD or presence of vitreous hemorrhage.Conclusion.The hsa-miR-148a-3p expression levels in the vitreous fluid were significantly associated with the size of retinal break and disease duration. |
| Databáze: | OpenAIRE |
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