Pregnancy improves neutropenia in T-cell large granular lymphocyte leukaemia
| Autor: | Claire Dearden, Estella Matutes, Daniel Catovsky, Nnenna Osuji |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Neutropenia Lymphocytosis Lymphocyte chemical and pharmacologic phenomena Biology Leukocyte Count Pregnancy Recurrence hemic and lymphatic diseases medicine Humans Progesterone Retrospective Studies Leukopenia Hematology medicine.disease Leukemia medicine.anatomical_structure T-Cell Large Granular Lymphocyte Leukemia Prolymphocytic T-Cell Immunology Cyclosporine Absolute neutrophil count Female medicine.symptom Pregnancy Complications Neoplastic Immunosuppressive Agents |
| Zdroj: | British Journal of Haematology. 128:645-648 |
| ISSN: | 1365-2141 0007-1048 |
| Popis: | The effect of pregnancy on T-cell large granular lymphocyte (LGL) leukaemia has not been previously described. We retrospectively reviewed the clinical features of three patients with T-cell LGL leukaemia; each of them had one or more pregnancies during disease evolution. Pregnancy was associated with sustained improvement in neutrophil count and concurrent reduction in lymphocytosis. Neutropenia returned in the non-pregnant state in all cases. A similar effect, induced by exogenous progesterone in one patient, suggests a role for progesterone in overcoming mechanisms of neutropenia in this disease. Pregnancy thus appears to have a beneficial effect on neutrophil count in T-cell LGL leukaemia. |
| Databáze: | OpenAIRE |
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