New Insights into Prevalence, Genetic Diversity, and Proviral Load of Human T-Cell Leukemia Virus Types 1 and 2 in Pregnant Women in Gabon in Equatorial Central Africa
| Autor: | Guillaume Besson, Maria Makuwa, Sonia Lekana-Douki Etenna, Antoine Mahé, Mirdad Kazanji, Antoine Gessain, Mélanie Caron |
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| Přispěvatelé: | Unité de Rétrovirologie, Centre International de Recherches Médicales de Franceville (CIRMF), Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Programme National de Lutte contre le Sida, Service de Coopération et d'Action Culturelle, French Embassy, Réseau International des Instituts Pasteur (RIIP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2008 |
| Předmět: |
MESH: Sequence Analysis
DNA Urban Population viruses Sequence Homology Simian MESH: Proviruses MESH: Genotype MESH: Pregnancy 0302 clinical medicine Proviruses Pregnancy Seroepidemiologic Studies immune system diseases hemic and lymphatic diseases Genotype Cluster Analysis Leukemia-Lymphoma Adult T-Cell MESH: Leukemia-Lymphoma Adult T-Cell MESH: Sequence Homology MESH: Genetic Variation 030212 general & internal medicine Pregnancy Complications Infectious MESH: Phylogeny Phylogeny Human T-lymphotropic virus 1 0303 health sciences Human T-lymphotropic virus 2 virus diseases Viral Load 3. Good health MESH: Urban Population [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Female MESH: Viral Load Viral load MESH: HTLV-II Infections Adult Microbiology (medical) MESH: Gabon Sexual transmission Adolescent Molecular Sequence Data Biology 03 medical and health sciences Virology Genetic variation Humans Seroprevalence MESH: Pregnancy Complications Infectious Gabon 030304 developmental biology MESH: Adolescent MESH: Humans MESH: Molecular Sequence Data MESH: Seroepidemiologic Studies MESH: Human T-lymphotropic virus 1 MESH: Human T-lymphotropic virus 2 Genetic Variation MESH: Adult Sequence Analysis DNA biology.organism_classification MESH: Cluster Analysis MESH: DNA Viral DNA Viral HTLV-II Infections MESH: Female |
| Zdroj: | Journal of Clinical Microbiology Journal of Clinical Microbiology, American Society for Microbiology, 2008, 46 (11), pp.3607-14. ⟨10.1128/JCM.01249-08⟩ Journal of Clinical Microbiology, 2008, 46 (11), pp.3607-14. ⟨10.1128/JCM.01249-08⟩ |
| ISSN: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.01249-08 |
| Popis: | Human T-cell leukemia virus type 1 (HTLV-1) is highly endemic in areas of central Africa; mother-to-child transmission and sexual transmission are considered to be the predominant routes. To determine the prevalence and subtypes of HTLV-1/2 in pregnant women in Gabon, we conducted an epidemiological survey in the five main cities of the country. In 907 samples, the HTLV-1 seroprevalence was 2.1%, which is lower than that previously reported. Only one case of HTLV-2 infection was found. The HTLV-1 seroprevalence increased with age and differed between regions ( P ≤ 0.05), with the highest prevalence (5%) in the southeastern region. A wide range of HTLV-1 proviral loads was observed among the infected women. The level of the proviral load was correlated with a high HTLV-1 antibody titer ( P ≤ 0.02). Sequencing of HTLV-1 env and long terminal repeat fragments showed that all but one strain belonged to the central African subtype B; the outlier was of cosmopolitan subtype A. The new strains of subtype B exhibited wide genetic diversity, but there was no evidence of clustering of specific genomes within geographical regions of the country. Some strains were closely related to simian T-cell leukemia virus type 1 strains of great apes, suggesting that in these areas some HTLV-1 strains could arise from relatively recent interspecies transmission. The sole HTLV-2 strain belonged to subtype B. In this study we showed that the prevalence of HTLV-1 in the southeast is one of the highest in the world for pregnant women. |
| Databáze: | OpenAIRE |
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