The erythrocyte membrane stability is associated with sleep time and social jetlag in shift workers

Autor: Luciana Alves de Medeiros, Emília Rezende Vaz, Thúlio Marquez Cunha, Kely R. C. Teixeira, Erick P. de Oliveira, Cibele Aparecida Crispim, Jordane Amaral Mendes, Nilson Penha-Silva
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Physiology
Biochemistry
Shift work
0302 clinical medicine
Animal Cells
Red Blood Cells
Medicine and Health Sciences
Medicine
Chronobiology
education.field_of_study
Multidisciplinary
Cell Death
medicine.diagnostic_test
Shift Work Schedule
Middle Aged
Lipids
Body Fluids
Circadian Rhythms
Cholesterol
Blood
Cell Processes
Cellular Types
Anatomy
medicine.symptom
Research Article
Adult
medicine.medical_specialty
Waist
Science
Population
Young Adult
03 medical and health sciences
Internal medicine
Humans
Hemoglobin
Circadian rhythm
education
Aged
Jet Lag Syndrome
Blood Cells
Cytolysis
business.industry
Erythrocyte Membrane
Biology and Life Sciences
Proteins
Cell Biology
Sleep deprivation
Cross-Sectional Studies
030104 developmental biology
Endocrinology
Blood pressure
Sleep Deprivation
Sleep
Physiological Processes
business
Lipid profile
030217 neurology & neurosurgery
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 9, p e0222698 (2019)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0222698
Popis: The osmotic stability of the erythrocyte membrane (OSEM) has been associated with changes in lipid profile, blood glucose and blood pressure. Changes in these parameters are very frequent in shift workers, possibly because of the lack of synchronization of biological rhythms, which results in the social jetlag. However, the existence of association between OSEM and circadian misalignment has not been investigated in this population. Therefore, this study investigated whether shift work, sleep time and social jetlag (SJL) are associated with biochemical and hematological variables. A population consisting of 79 men working at night (n = 37) or during the day (n = 42), aged between 21 and 65 years and with a mean BMI of 27.56 ± 4.0 kg/m2, was investigated cross-sectionally in relation to sleep time, SJL, anthropometric (height, weight and waist circumference) and blood variables, with emphasis on the OSEM. SJL was calculated by the absolute difference between the midpoint of sleep on work and rest days. The Generalized Linear Model (GzLM) was used to investigate the existence of associations between SJL and average sleep time in relation to the analyzed variables. Workers without SJL presented lower baseline lysis values of erythrocytes in isotonic medium in relation to workers with SJL. In addition, workers who slept on average less than 6 hours had higher OSEM, and higher total and LDL-cholesterol in relation to those who slept more than 6 hours, regardless of the shift. It is possible that the association of sleep deprivation and SJL with erythrocyte membrane stability is mediated through changes in the lipid profile.
Databáze: OpenAIRE
Externí odkaz: