Palladium-Catalyzed Oxidative Coupling of the Allenic C–H Bond with α-Diazo Esters: Synthesis of [3]Dendralenes

Autor: Shichao Li, Bo Hou, Jianbo Wang
Rok vydání: 2021
Předmět:
Zdroj: The Journal of Organic Chemistry. 86:5371-5379
ISSN: 1520-6904
0022-3263
Popis: A palladium-catalyzed highly regio- and stereoselective allenic C-H oxidative coupling with α-diazo esters is developed. The reaction pathway involves allylic palladium carbene as the key intermediate, which is followed by a carbene migratory insertion process. The reaction proceeds efficiently under mild conditions without external base, providing substituted [3]dendralenes bearing various functional groups.
Databáze: OpenAIRE