Palladium-Catalyzed Oxidative Coupling of the Allenic C–H Bond with α-Diazo Esters: Synthesis of [3]Dendralenes
| Autor: | Shichao Li, Bo Hou, Jianbo Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Allylic rearrangement
C h bond 010405 organic chemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Diazo Stereoselectivity Oxidative coupling of methane Carbene Palladium |
| Zdroj: | The Journal of Organic Chemistry. 86:5371-5379 |
| ISSN: | 1520-6904 0022-3263 |
| Popis: | A palladium-catalyzed highly regio- and stereoselective allenic C-H oxidative coupling with α-diazo esters is developed. The reaction pathway involves allylic palladium carbene as the key intermediate, which is followed by a carbene migratory insertion process. The reaction proceeds efficiently under mild conditions without external base, providing substituted [3]dendralenes bearing various functional groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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