A first screening for hemocompatibility of a universal support for selective and specific hemoperfusion
| Autor: | H. Klinkmann, Böttcher M, B. Ernst, F.M. Everaerts, M.L.P.M. Verhoeven, L.A.A.E. Sluyterman |
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| Přispěvatelé: | Chemical Engineering and Chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 1989 |
| Předmět: |
Chromatography
Ligand Sodium periodate medicine.medical_treatment Biomedical Engineering Albumin Medicine (miscellaneous) Bioengineering ComputingMilieux_LEGALASPECTSOFCOMPUTING General Medicine Borane Hemoperfusion Biomaterials chemistry.chemical_compound chemistry medicine Glutaraldehyde Cellulose |
| Zdroj: | International Journal of Artificial Organs, 12(1), 63-67. Wichtig Publishing |
| ISSN: | 0391-3988 |
| Popis: | A modified filmadsorber is presented, intended to be used for selective and spe cific hemoperfusion. It consists of a spirally wound cellulose nitrate film, onto which - after chemical activation with sodium periodate - albumin is bound, stabilized, sterilized and acti vated with glutaraldehyde. Various bioactive ligands containing amino groups can be coupled to this support. A subsequent treatment with dimethylamino borane stabilizes the bonds be tween cellulose nitrate, albumin, glutaraldehyde and ligand. Columns in which a second layer of albumin is bound to the support as a model for a bioactive ligand were first screened for hemocompatibility using rabbits. Leukocyte, thrombocyte and hematocrit behaviour during hemoperfusion showed that hemocompatibility of the support was good. (Int J Artif Organs, 1989; 12:63-7) \ |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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