The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures
| Autor: | Emine M Onal, Mehmet Kanbay, Oguzhan Sal, Alan A. Sag, Yagmur Kilic |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Embryology Organogenesis Endocrinology Diabetes and Metabolism Drug Resistance Tretinoin Computational biology 030204 cardiovascular system & hematology Kidney Hypertension Therapy Treatment failure Thiazides 03 medical and health sciences 0302 clinical medicine Treatment targets Internal Medicine Data Mining Humans Medicine Treatment Failure business.industry Dopaminergic Neurons Patient management Crosstalk (biology) 030104 developmental biology Molecular Medicine Essential Hypertension Cardiology and Cardiovascular Medicine business |
| Zdroj: | J Clin Hypertens (Greenwich) |
| ISSN: | 1524-6175 |
| DOI: | 10.1111/jch.12978 |
| Popis: | This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug‐resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician‐directed fashion. |
| Databáze: | OpenAIRE |
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