Stable and Antibacterial Magnesium-Graphene Nanocomposite-Based Implants for Bone Repair
| Autor: | Safari, Narges, Golafshan, Nasim, Kharaziha, Mahshid, Toroghinejad, Mohammad Reza, Utomo, Lizette, Malda, Jos, Castilho, Miguel, Chirurgie, Equine Musculoskeletal Biology, dES RMSC |
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| Přispěvatelé: | Chirurgie, Equine Musculoskeletal Biology, dES RMSC, EAISI Health, ICMS Affiliated, Orthopaedic Biomechanics |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
0206 medical engineering Alloy Biomedical Engineering Spark plasma sintering chemistry.chemical_element 02 engineering and technology Bone healing engineering.material Corrosion Nanocomposites Biomaterials magnesium alloys Absorbable Implants medicine Humans Magnesium antibacterial properties degradation Nanocomposite corrosion resistance bone implants technology industry and agriculture 021001 nanoscience & nanotechnology equipment and supplies 020601 biomedical engineering Copper Anti-Bacterial Agents medicine.anatomical_structure chemistry engineering Graphite 0210 nano-technology Cancellous bone Nuclear chemistry |
| Zdroj: | ACS Biomaterials Science and Engineering, 6(11), 6253. American Chemical Society ACS Biomaterials Science and Engineering, 6(11), 6253-6262. American Chemical Society |
| ISSN: | 2373-9878 |
| Popis: | Magnesium (Mg)-based alloys are promising biodegradable materials for bone repair applications. However, due to their rapid degradation and high corrosion rate, Mg-based alloys are typically associated with in vivo infections and implant failure. This study evaluated the synergistic stability and anti-inflammatory properties that could potentially be achieved by the modification of the Mg alloy with graphene nanoparticles (Gr). Incorporation of low dosages of Gr (0.18 and 0.50 wt %) in a Mg alloy with aluminum (Al, 1 wt %) and copper (Cu, 0.25 wt %) was successfully achieved by a spark plasma sintering (SPS) method. Notably, the degradation rate of the Mg-based alloys was reduced approximately 4-fold and the bactericidal activity was enhanced up to 5-fold with incorporation of only 0.18 wt % Gr to the Mg-1Al-Cu matrix. Moreover, the modified Mg-based nanocomposites with 0.18 wt % Gr demonstrated compressive properties within the range of native cancellous bone (modulus of approximately 6 GPa), whereas in vitro studies with human mesenchymal stromal cells (hMSCs) showed high cytocompatibility and superior osteogenic properties compared to non-Gr-modified Mg-1Al-Cu implants. Overall, this study provides foundations for the fabrication of stable, yet fully resorbable, Mg-based bone implants that could reduce implant-associated infections. |
| Databáze: | OpenAIRE |
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