APOE polymorphisms and cognitive functions in patients with brain tumors
| Autor: | Jaya M. Satagopan, Richards Elizabeth C, Raymond E. Baser, Kenneth Cheung, Denise D. Correa, Sasan Karimi, Michael T. Lin, Lisa M. DeAngelis, John K. Lyo, Irene Orlow |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology Apolipoprotein E medicine.medical_specialty Pathology Genotyping Techniques Apolipoprotein E4 Single-nucleotide polymorphism Neuropsychological Tests Verbal learning Nerve Fibers Myelinated Polymorphism Single Nucleotide Executive Function Apolipoproteins E Internal medicine medicine Humans Allele Alleles Aged Aged 80 and over Memory Disorders Polymorphism Genetic Brain Neoplasms Working memory Smoking Neuropsychology Brain Middle Aged Magnetic Resonance Imaging Multivariate Analysis Female Neurology (clinical) Cognition Disorders Psychology Executive dysfunction |
| Zdroj: | Neurology. 83:320-327 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.0000000000000617 |
| Popis: | Objective: The goal of this study was to assess whether the APOE e4 allele and other APOE single nucleotide polymorphisms (SNPs) influence neuropsychological and neuroimaging outcomes in patients with brain tumors. Methods: Two hundred eleven patients with brain tumors participated in the study. All patients completed standardized neuropsychological tests and provided a blood sample for APOE genotyping. Ratings of white matter abnormalities were performed on MRI scans. Patients were classified into 2 groups based on the presence (n = 50) or absence (n = 161) of at least one APOE e4 allele. Additional APOE SNPs were genotyped in a subset of 150 patients. Results: Patients with at least one APOE e4 allele had significantly lower scores in verbal learning and delayed recall, and marginally significant lower scores in executive function, in comparison to noncarriers of an e4 allele. Patients with at least one e4 allele and history of cigarette smoking had significantly higher scores in working memory and verbal learning than e4 carriers who never smoked. Nine additional APOE SNPs were significantly associated with attention and executive and memory abilities. There were no significant differences between e4 carriers and noncarriers on the extent of white matter abnormalities on MRI. Conclusions: The findings suggest that patients with brain tumors who are carriers of the APOE e4 allele may have increased vulnerability to developing memory and executive dysfunction, and that additional SNPs in the APOE gene may be associated with cognitive outcome. |
| Databáze: | OpenAIRE |
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