The effect of iron-vitamin C co-supplementation on biomarkers of oxidative stress in iron-deficient female youth
| Autor: | Arash Rashidi, Fatemeh Mohammadi, Sima Mortazavi, Mohammad Reza Khoshfetrat, Naser Kalantari, Ahmad Esmaillzadeh, Tirang R. Neyestani |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Antioxidant Adolescent Anemia Endocrinology Diabetes and Metabolism medicine.medical_treatment Iron Clinical Biochemistry Ascorbic Acid medicine.disease_cause Biochemistry Inorganic Chemistry chemistry.chemical_compound Double-Blind Method Internal medicine medicine Humans chemistry.chemical_classification Reactive oxygen species Vitamin C Anemia Iron-Deficiency Biochemistry (medical) General Medicine Iron deficiency medicine.disease Ascorbic acid Malondialdehyde Oxidative Stress Endocrinology chemistry Immunology Female Oxidative stress Biomarkers |
| Zdroj: | Biological trace element research. 153(1-3) |
| ISSN: | 1559-0720 |
| Popis: | There is no study that assessed the effect of co-supplementation of iron and vitamin C on biomarkers of oxidative stress in non-anemic iron-deficient females. We investigated the effects of iron vs. iron + vitamin C co-supplementation on biomarkers of oxidative stress in iron-deficient girls. In a double-blind randomized controlled clinical trial, performed among 60 non-anemic iron-deficient girls, participants were randomly assigned to receive either 50 mg/day elemental iron supplements or 50 mg/day elemental iron + 500 mg/day ascorbic acid for 12 weeks. Fasting blood samples were taken at baseline, weeks 6 and 12 for assessment of biomarkers of oxidative stress. Compared with the baseline levels, both iron and iron + vitamin C supplementation resulted in a significant reduction in serum malondialdehyde (MDA) levels (P time < 0.001) and remarkable elevation in serum total antioxidant capacity (TAC; P time < 0.001) and vitamin C levels (P time = 0.001); however, comparing the two groups we failed to find an additional effect of iron + vitamin C supplementation to that of iron alone on serum TAC and MDA levels (P group was not statistically significant). Iron + vitamin C supplementation influenced serum vitamin C levels much more than that by iron alone (P group < 0.01). We also found a significant interaction term between time and group about serum vitamin C levels while this interaction was not significant about serum TAC and MDA levels. In conclusion, we found that iron supplementation with/without vitamin C improve biomarkers of oxidative stress among non-anemic iron-deficient females and may strengthen the antioxidant defense system by decreasing reactive oxygen species. Co-supplementation of iron + vitamin C has no further effect on oxidative stress compared with iron alone. |
| Databáze: | OpenAIRE |
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