The Cephalogastric Phase of the Pancreatic Response to Food in the Dog
| Autor: | M.A. Devaux, C. D. Johnson, Henri Sarles, Treffot Mj |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Atropine
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Vagotomy digestive system Parasympatholytic Secretin Eating Dogs Endocrinology Vagotomy Truncal Internal medicine Gastrins Reflex Pyloric Antrum Internal Medicine medicine Animals Pancreas Antrum Gastrin Hepatology Gastric emptying Chemistry Stomach digestive oral and skin physiology Vagus Nerve medicine.anatomical_structure Gastric Emptying Duodenum hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Pancreas. 6:190-196 |
| ISSN: | 0885-3177 |
| DOI: | 10.1097/00006676-199103000-00010 |
| Popis: | We studied post-meal pancreatic secretion and gastrin release in conscious dogs with duodenal Thomas cannulas. Normal dogs were tested in physiological conditions and with an i.v. infusion of atropine 20 micrograms/kg/h or secretin 0.5 CU/kg/h. The responses were also studied after antral and truncal vagotomy. In the early phase (0-20 min) of the response, before gastric emptying started, antral vagotomy reduced fluid and protein outputs, and truncal vagotomy reduced them still more. Atropine reduced only the protein response. Gastrin release reached a peak after 20-25 min. After antral and truncal vagotomy, gastrin release was reduced within 10 min after the meal. Late-phase (greater than 20 min) pancreatic secretion depended on the presence of chyme in the duodenum. The effects of atropine and antral vagotomy in the cephalogastric phase could be explained by antropancreatic reflexes stimulating fluid secretion (atropine-resistant pathway) and protein output (atropine-sensitive pathway). |
| Databáze: | OpenAIRE |
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