Nuclear localization of translocation partners in differentiating B-cells
Autor: | I. V. Sklyar, E. S. Vassetzky, Olga V. Iarovaia, Sergey V. Razin, Andrey Pichugin |
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Rok vydání: | 2015 |
Předmět: |
Nucleolus
Cellular differentiation Active Transport Cell Nucleus Biophysics chemical and pharmacologic phenomena Chromosomal translocation Locus (genetics) Biology Bioinformatics Biochemistry Proto-Oncogene Proteins c-myc hemic and lymphatic diseases medicine Cyclin D1 Allele Alleles Cell Nucleus B-Lymphocytes Cell Differentiation General Chemistry General Medicine Cell biology Cell nucleus medicine.anatomical_structure Genetic Loci Immunoglobulin heavy chain Immunoglobulin Heavy Chains Nuclear localization sequence |
Zdroj: | Doklady Biochemistry and Biophysics. 464:312-314 |
ISSN: | 1608-3091 1607-6729 |
Popis: | We studied the nuclear localization and relative position in the nuclear space of malignant translocation partner genes c-Myc, CCND1, and IGH locus in naive and differentiating B cells. We have shown that, during B-cell maturation, c-Myc and IGH loci become closer to each other. In differentiating lymphocytes, those alleles of c-Myc and IGH that are in close spatial proximity to each other are closer to the nucleolus. For the CCND1 locus, no correlation between the proximity of loci and nuclear localization was found. These data suggest that the close spatial proximity of c-Myc and IGH loci during B-cell maturation increase the probability of malignant translocation. |
Databáze: | OpenAIRE |
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