Targeting Free Radicals in Oxidative Stress-Related Human Diseases
| Autor: | Patrik Poprac, Christopher J. Rhodes, Miriama Simunkova, Klaudia Jomová, Vojtech Kollar, Marian Valko |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antioxidant Free Radicals medicine.medical_treatment Pharmacology Toxicology medicine.disease_cause Neuroprotection Antioxidants Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Alzheimer Disease Neoplasms medicine Humans Chelating Agents chemistry.chemical_classification Reactive oxygen species biology Glutathione Free Radical Scavengers Oxidative Stress 030104 developmental biology chemistry Biochemistry Cancer cell biology.protein Thioredoxin Reactive Oxygen Species Oxidative stress |
| Zdroj: | Trends in pharmacological sciences. 38(7) |
| ISSN: | 1873-3735 |
| Popis: | Cancer and Alzheimer's disease (AD) are characterized by (i) opposing biological mechanisms, (ii) an inverse correlation between their incidences, and (iii) oxidative stress being a common denominator of both diseases. Increased formation of reactive oxygen species (ROS) in cancer cells from oncogenic signaling and/or metabolic disturbances leads to upregulation of cellular antioxidant capacity to maintain ROS levels below a toxic threshold. Combining drugs that induce high levels of ROS with compounds that suppress cellular antioxidant capacity by depleting antioxidant systems [glutathione (GSH), superoxide dismutase (SOD), and thioredoxin (TRX)] and/or targeting glucose metabolism represents a potential anticancer strategy. In AD, free metals and/or Aβ:metal complexes may cause damage to biomolecules in the brain (via Fenton reaction), including DNA. Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy. This review examines therapeutic strategies based on the modulation of oxidative stress in cancer and AD. |
| Databáze: | OpenAIRE |
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