Developmental Toxicity of Carbon Quantum Dots to the Embryos/Larvae of Rare Minnow (Gobiocypris rarus)
| Autor: | Ming-Zhi Liu, Yao Chen, Li Jin, Li Liu, Yuan-Yuan Xiao, Yu-Lian Zeng |
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| Rok vydání: | 2016 |
| Předmět: |
Article Subject
Developmental toxicity lcsh:Medicine 02 engineering and technology 010501 environmental sciences medicine.disease_cause 01 natural sciences General Biochemistry Genetics and Molecular Biology Andrology Downregulation and upregulation biology.animal medicine Yolk sac 0105 earth and related environmental sciences General Immunology and Microbiology biology lcsh:R Embryo General Medicine Anatomy Minnow 021001 nanoscience & nanotechnology biology.organism_classification medicine.anatomical_structure Gobiocypris rarus Toxicity 0210 nano-technology Oxidative stress |
| Zdroj: | BioMed Research International, Vol 2016 (2016) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2016/4016402 |
| Popis: | The toxic effects of CDs on rare minnow (Gobiocypris rarus) embryos at different developmental stages were investigated. The results showed that rare minnow embryos had decreased spontaneous movements, body length, increased heart rate, pericardial edema, yolk sac edema, tail/spinal curvature, various morphological malformations, and decreased hatching rate. Biochemical analysis showed the CDs exposure significantly inhibited the activity of Na+/K+-ATPase and Ca2+-ATPase and increased the MDA contents and the activity of SOD, CAT, and GPX. Further examination suggested that the CDs exposure induced serious embryonic cellular DNA damage. Moreover, the CDs exposure induced upregulation of development related genes (Wnt8aandMstn) along with the downregulation ofVezf1. Overall, the present study revealed that the CDs exposure has significant development toxicity on rare minnow embryos/larvae. Mechanistically, this toxicity might result from the pressure of induced oxidative stress coordinate with the dysregulated development related gene expression mediated by the CDs exposure. |
| Databáze: | OpenAIRE |
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