Cutaneous Metastasis From Large-Cell Neuroendocrine Carcinoma of the Urinary Bladder Expressing CK20 and TTF-1
| Autor: | Woo Jin Lee, Chae Hwa Kim, Jee Ho Choi, Sung Eun Chang, Mi Woo Lee, Jai Kyoung Koh, Kee Chan Moon |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lung Neoplasms Skin Neoplasms Biopsy medicine.medical_treatment Dermatology Pathology and Forensic Medicine Cystectomy Antibodies Monoclonal Murine-Derived Young Adult Cytokeratin Fatal Outcome Carcinoma medicine Humans Scalp Urinary bladder medicine.diagnostic_test business.industry Thyroid Antibodies Monoclonal Cancer General Medicine medicine.disease DNA-Binding Proteins Neuroendocrine Tumors medicine.anatomical_structure Urinary Bladder Neoplasms Lymphatic Metastasis Carcinoma Large Cell Rituximab Merkel cell business Biomarkers Transcription Factors |
| Zdroj: | The American Journal of Dermatopathology. 31:166-169 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/dad.0b013e31818eba4c |
| Popis: | Large-cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is very rare. Immunohistochemical and biochemical examinations have shown that neuroendocrine carcinomas (NECs) have features of neuroendocrine and epithelial differentiation. We describe the first case of cutaneous metastasis from LCNEC of the urinary bladder. The patient had been treated with partial cystectomy and chemotherapy for LCNEC of the urinary bladder, but a year later, he visited our clinic with a reddish mass on his scalp that was diagnosed as a cutaneous metastasis from LCNEC. The tumor cells were positive for the neuroendocrine markers, cytokeratin (CK) 20 and thyroid transcription factor-1. Most NECs, except for Merkel cell carcinomas, do not express CK20, whereas most urothelial carcinomas do express CK20. These results suggest that a histogenetic link may exist between NEC of the urinary bladder and urothelial carcinoma. |
| Databáze: | OpenAIRE |
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