Fetuin-A levels in obesity: differences in relation to metabolic syndrome and correlation with clinical and laboratory variables
| Autor: | Abeer Abd ElBaky, Hala M. Koura, Nagwa Abdallah Ismail, Nehal Salah, Mona Hamed, Soha M. Abd El Dayem, Heba Sayed Assal, Shadia Ragab |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
obesity
medicine.medical_specialty Waist business.industry Insulin medicine.medical_treatment General Medicine Anthropometry medicine.disease Obesity metabolic syndrome Endocrinology Blood pressure Insulin resistance Clinical Research insulin resistance Internal medicine Medicine Metabolic syndrome business fetuin A National Cholesterol Education Program |
| Zdroj: | Archives of Medical Science : AMS |
| ISSN: | 1734-1922 |
| DOI: | 10.5114/aoms.2012.31616 |
| Popis: | Introduction: Fetuin-A is an important player in the enhancement of insulin resistance. There are very limited data available concerning the relationships between fetuin-A, weight status and features of the metabolic syndrome (Met S) in obese Egyptian subjects, and especially in children. The aim of the study was to evaluate fetuin-A serum level in subjects with obesity and its possible asso- ciation with other laboratory and clinical variables. Material and methods: A total of 140 obese subjects and 50 controls aged 10-40 years were recruited. Demographic, anthropometric and biochemical features were collected according to a standard protocol. Serum fetuin-A levels were measured using ELISA and the modified Third Report of the National Cholesterol Education Program (NCEP-ATP III) criteria were adopted to diagnose Met S. Results: A higher level of serum fetuin-A was detected in obese subjects. Met S cases were also significantly associated with higher serum fetuin-A. Fetuin-A correlated significantly with BMI (r = 0.437), systolic (r = 0.228) and diastolic blood pressure (r = 0.295), waist circumference (r = 0.332), insulin resist- ance calculated by the homeostasis model (HOMA-IR) (r = 0.295) and high-den- sity lipoprotein (HDL) (r = 0.362). Conclusions: Fetuin-A levels were higher in adults and children with obesity and Met S. They were related to insulin resistance and to features of the Met S in cross-sectional analyses. Our study demonstrates a novel association between human fetuin-A and the Met S among obese subject. Therefore, fetuin-A might be a new promising link between obesity and its comorbidities. |
| Databáze: | OpenAIRE |
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