Neurocognitive Function of School-aged HIV-infected Children in Enugu, Nigeria
| Autor: | Ogochukwu N Iloh, Adaeze C Ayuk, Anthony N Ikefuna, Ngozi S Ibeziako, Ifeoma J Emodi, GC Ilechukwu, Agozie C Ubesie, Kenechukwu K Iloh |
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| Rok vydání: | 2017 |
| Předmět: |
Pediatrics
medicine.medical_specialty Paediatric clinic School age child Pediatric hiv business.industry Human immunodeficiency virus (HIV) Nigerian population medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Infectious Diseases Raven's Progressive Matrices 030225 pediatrics Hiv infected Pediatrics Perinatology and Child Health Medicine business Neurocognitive 030217 neurology & neurosurgery |
| Zdroj: | Journal of Tropical Pediatrics. 63:425-430 |
| ISSN: | 1465-3664 0142-6338 |
| DOI: | 10.1093/tropej/fmx006 |
| Popis: | BACKGROUND Evidence has shown neurocognitive problems often exist among human immunodeficiency virus (HIV)-infected children. There are limited data for children in Nigeria. METHODS This was a cross-sectional study of 100 school-aged perinatally HIV-infected children seen in the paediatric HIV clinic and age/sex-matched controls from the general paediatric clinic. Neuro-cognitive functioning was assessed using the Raven's progressive matrices (RPM) that has been adapted for the Nigerian population. RESULTS The mean RPM score of subjects was 22.97 ± 11.35 compared with 32.93 ± 15.71 among controls (p < 0.001). Twenty-two percent of subjects in the HIV-infected group vs. 56% of controls were in the above-average intelligence group on the RPM. Thirty-four percent had average scores, while 22% were in the below-average scoring range. Neuro-cognitive functioning of the subjects was significantly affected by immunologic staging and socio-economic status. CONCLUSIONS Neurocognitive functioning of the HIV-infected children was significantly lower than those of their un-infected counterparts. Neurodevelopmental evaluation should be part of standard care in HIV-infected children in Nigerian setting. |
| Databáze: | OpenAIRE |
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