Enteral bioactive factor supplementation in preterm infants
| Autor: | Letty van Toledo, Johannes B. van Goudoever, Jacqueline Limpens, Eva F.G. Naninck, Elise Mank, Chris H.P. van den Akker |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Vitamin
medicine.medical_specialty Databases Factual MEDLINE lcsh:TX341-641 Review Enteral administration law.invention 03 medical and health sciences chemistry.chemical_compound Child Development Enteral Nutrition 0302 clinical medicine Randomized controlled trial law 030225 pediatrics medicine Humans 030212 general & internal medicine Infant Nutritional Physiological Phenomena Intensive care medicine Randomized Controlled Trials as Topic Nutrition Nutrition and Dietetics Milk Human business.industry Human milk Therapeutic effect Infant Trophic factor Premature neonate Clinical trial Treatment Outcome Systematic review Parenteral nutrition chemistry Dietary Supplements business lcsh:Nutrition. Foods and food supply Infant Premature Food Science |
| Zdroj: | Nutrients Nutrients, Vol 12, Iss 2916, p 2916 (2020) Mank, E, Naninck, E F G, Limpens, J, van Toledo, L, van Goudoever, J B & van den Akker, C H P 2020, ' Enteral bioactive factor supplementation in preterm infants : A systematic review ', Nutrients, vol. 12, no. 10, 2916, pp. 1-26 . https://doi.org/10.3390/nu12102916 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12102916 |
| Popis: | Feeding preterm infants with mother’s own milk is associated with a reduction in postnatal complications and an improved neurocognitive outcome. Therefore, the bioactive factor composition of human milk has been used as a tool for the development of nutritional supplements with a potential prophylactic or therapeutic effect. The aim of this systematic review was to provide an overview on bioactive factors which have been studied as supplement to enteral nutrition in randomized controlled trials, and to provide an overview of ongoing trials. MEDLINE, EMBASE, CENTRAL, and clinical trial registers were searched. Studies on the antimicrobial protein lactoferrin were excluded as these were summarized very recently in three separate systematic reviews. Studies on vitamins D, K and iron were also excluded as they are already incorporated in most international guidelines. We identified 17 different bioactive factors, which were investigated in 26 studies. Despite the encouraging potential effects of several bioactive factors, more high-quality studies with a sufficient number of preterm infants are required before a certain factor may be implemented into clinical practice. Three large trials (n > 500) that investigate the effects of either enteral insulin or vitamin A are currently ongoing and could provide more definite answers on these specific supplements. |
| Databáze: | OpenAIRE |
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