Randomized clinical trial of two anesthetic techniques for intravitreal injections: 4% liquid lidocaine on cotton swabs versus 3.5% lidocaine gel
| Autor: | Ninel Z. Gregori, Matthew J. Weiss, Vilma Hernandez, Wei Shi, Raquel Goldhardt, Linda Kelley, Joyce C. Schiffman, William J. Feuer, Cherrie Ann Mattis, Edgardo Vega |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Lidocaine Administration Topical Pain Pharmaceutical Science law.invention Randomized controlled trial Pain control law medicine Humans Prospective Studies Anesthetics Local Prospective cohort study Aged Pain Measurement Aged 80 and over business.industry Outcome measures Middle Aged Surgery Needle penetration Anesthesia Intravitreal Injections Anesthetic Female Subconjunctival hemorrhage business Gels medicine.drug |
| Zdroj: | Expert Opinion on Drug Delivery. 9:735-741 |
| ISSN: | 1744-7593 1742-5247 |
| Popis: | To compare same-day and next-day pain control and safety of two anesthetic techniques utilizing 4% liquid lidocaine applied with sterile cotton swabs versus 3.5% lidocaine gel for intravitreal injections. Main outcome measures were: discomfort during anesthetic preparation and needle penetration, 1 and 24 h after injection.Patients were randomized to alternate anesthetic method at two consecutive injections in one eye or in different eyes on the same day if requiring bilateral injections. Overall satisfaction, corneal staining, and subconjunctival hemorrhage (SCH) were compared.Fifty patients were enrolled. Both methods resulted in similar mild discomfort during anesthetic preparation, 1 and 24 h later. The gel resulted in slightly higher discomfort during needle penetration (p = 0.026). Patients were satisfied with both techniques (p = 0.91), however, 52% patients preferred gel, 33% were indifferent, and 15% preferred cotton swabs (p = 0.002). There were significantly less corneal staining (p = 0.001) and SCH (p = 0.004) after the gel.Both techniques are equally effective and yield mild discomfort scores during the procedure and the next day. The gel method results in significantly less ocular surface irritation. |
| Databáze: | OpenAIRE |
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