Co-delivery of docetaxel and bortezomib based on a targeting nanoplatform for enhancing cancer chemotherapy effects

Autor:	Yinping Wei, Lin Mei, Wei Cheng, Gan Liu, Chaoyu Liang, Xiaowei Zeng, Wei Tao, Yunmei Peng, Yuhan Chen, Junpeng Nie, Xusheng Wang
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Drug Biodistribution Materials science media_common.quotation_subject education Pharmaceutical Science cancer nanotechnology targeting nanoplatform 02 engineering and technology Docetaxel RM1-950 Pharmacology 010402 general chemistry 01 natural sciences Bortezomib co-delivery chemistry.chemical_compound In vivo ph-response Neoplasms medicine Humans Tissue Distribution Lactic Acid polydopamine media_common technology industry and agriculture General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Drug delivery Surface modification Nanoparticles Taxoids Therapeutics. Pharmacology 0210 nano-technology Ethylene glycol medicine.drug Research Article
Zdroj:	Drug Delivery, Vol 24, Iss 1, Pp 1124-1138 (2017) Drug Delivery article-version (VoR) Version of Record
ISSN:	1521-0464 1071-7544
Popis:	Using facile polydopamine (PDA)-based surface modification and a pH-sensitive catechol-boronate binding mechanism, a novel drug delivery system was designed for the treatment of breast cancer. The system was able to achieve the following goals: active targeting, pH responsiveness, in vivo blood circulation for a prolonged period of time, and dual drug loading. After coating with PDA, the docetaxel (DTX)-loaded star-shaped copolymer cholic acid-poly(lactide-co-glycolide) nanoparticles (CA-PLGA@PDA/NPs) were functionalized with amino-poly(ethylene glycol)-folic acid (NH2-PEG-FA) and bortezomib (BTZ) to form the targeting composition, DTX-loaded CA-PLGA@PDA-PEG-FA + BTZ/NPs. The novel NPs exhibited similar drug release characteristics compared to unfunctionalized CA-PLGA/NPs. Meanwhile, the incorporated NH2-PEG-FA contributed to active targeting which was illustrated by cellular uptake experiments and biodistribution studies. Moreover, the pH responsive binding between BTZ and PDA was demonstrated to be effective to release BTZ at the tumor acidic environment for synergistic action with DTX. Both in vitro cytotoxicity and in vivo antitumor studies demonstrated that the novel nanoplatform exhibited the most suitable therapeutic effects. Taken together, the versatile PDA modified DTX-loaded CA-PLGA@PDA-PEG-FA + BTZ/NPs offered a promising chemotherapeutic strategy for enhancing breast cancer treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cc247d08dfb8f193e12e352b66ce3c https://doaj.org/article/3c54aa2634dd4f0e80c177b5e2a2135a Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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