Endogenous regulation of the functional duality of pahutoxin, a marine trunkfish surfactant
| Autor: | Eliahu Kalmanzon, Shmuel Carmeli, Eliahu Zlotkin, Yocheved Rahamim, Yechezkel Barenholz |
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| Rok vydání: | 2004 |
| Předmět: |
Time Factors
Phospholipid Endogeny Complement factor I Biology urologic and male genital diseases Toxicology medicine.disease_cause Permeability Choline Surface-Active Agents chemistry.chemical_compound Pulmonary surfactant medicine Animals Secretion Skin Tetraodontiformes Toxin Biological activity Sea Bream chemistry Biochemistry Liposomes Toxicity Marine Toxins |
| Zdroj: | Toxicon. 44:939-942 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2004.07.029 |
| Popis: | Pahutoxin (PHN) is a long chain detergent—like quaternary ammonium cationic substance derived from defensive skin secretions of trunkfish. A recent study has revealed that PHN's ichthyotoxicity and its phospholipid membrane disruption effect are produced by two separate mechanisms, which presumably represent two separate physicochemical domains in the PHN molecule [Kalmanzon, E., Rahamim, Y., Barenholz, Y., Carmeli, S., Zlotkin, E., 2003. Receptor-mediated toxicity of pahutoxin, a marine trunkish surfactant. Toxicon 42, 63–71] . Here we report on the occurrence of a natural endogenous mechanism, which regulates the above PHN's functional duality. The regulation is performed by the aid of two separates constituents of the trunkfish secretion, which either selectively amplify PHN's ichthyotoxicity (factor I) or suppress its phospholipids permeabilization effect (factor II). The ecological significance of such endogenous regulation is discussed. |
| Databáze: | OpenAIRE |
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