The distribution of [3H]-dibromodulcitol in the central nervous system of patients with brain tumour
| Autor: | S. Eckhardt, S. Kerpel-Fronius, I.P. Horváth, Dénes Áfra, L. Institoris, J. Csetényi |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
Pathology Time Factors Brain Neoplasms Central nervous system Administration Oral Brain Drug administration Glioma Biology Drug Administration Schedule White matter Kinetics Mitolactol Endocrinology medicine.anatomical_structure Cerebrospinal fluid Oncology Internal medicine medicine Humans Distribution (pharmacology) |
| Zdroj: | European Journal of Cancer and Clinical Oncology. 19:1389-1392 |
| ISSN: | 0277-5379 |
| Popis: | The uptake of [ 3 H ]-dibromodulcitol ([ 3 H ]-DBD) into glioblastomas, white matter and cerebrospinal fluid was studied in 10 patients. Single-tissue samples were taken from different subjects at 4, 15 and 24 hr after [ 3 H ]-DBD administration. The level of 3 H -compounds in the central nervous system was similar after a single (400 mg/m 2 ), or 3 smaller daily oral doses of 150–180 mg/m 2 of [ 3 H ]-DBD. The distribution of radioactivity was uniform in the tumour, white matter and muscle. Between 3 and 15 hr after administration of DBD the concentration of radioactivity did not change significantly and was between 5 and 13 μg of DBD/ g tissue wet wt. At the same time the level in the cerebrospinal fluid (CSF) remained between 1 and 4 μg/ml . Meanwhile, the average concentration of radioactivity in the plasma fell from 11 to 3 μg/ml . The elimination half-life of the labelled compounds from the tissues was about 1 day as judged from the limited number of non-serial data obtained 4 and 24 hr after the last dose of repeated drug administration. |
| Databáze: | OpenAIRE |
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