Effect of calcium dobesilate on retrobulbar blood flow and choroidal thickness in patients with non-proliferative diabetic retinopathy
| Autor: | Mohammad Reza Khalili, Hossein Ashraf, Maryam Akbari, Hamidreza Jahanbani-Ardakani, Mehrzad Lotfi, Morteza Ghaffari |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Central retinal artery Retinal Artery Blood–retinal barrier Calcium dobesilate Calcium Dobesilate Ciliary Arteries Ophthalmic Artery medicine.artery Ophthalmology Diabetes mellitus Diabetes Mellitus medicine Humans Ultrasonography Doppler Color Aged Diabetic Retinopathy business.industry Diabetic retinopathy Blood flow Middle Aged medicine.disease Ciliary arteries medicine.anatomical_structure Regional Blood Flow Ophthalmic artery business Blood Flow Velocity medicine.drug |
| Zdroj: | International Ophthalmology. 41:3479-3486 |
| ISSN: | 1573-2630 0165-5701 |
| DOI: | 10.1007/s10792-021-01914-x |
| Popis: | Diabetic retinopathy is one of the most common causes of blindness in work-aging adults and develops in one third of diabetic patients. Calcium dobesilate (CaD) treatment have protective effects on blood retinal barrier (BRB) and anti-oxidant as well as anti-inflammatory properties. To assess effects of CaD administration on retrobulbar blood flow and choroidal thickness in patients with diabetic retinopathy. In this quasi-experimental study, diabetic patients with diabetic retinopathy (DR) were recruited from Shahid Motahari and Poostchi ophthalmology clinic affiliated to Shiraz University of Medical Sciences. Patients were treated with CaD, 1 gr per day for seven days. Before and after CaD administration, retrobulbar blood flow and subfoveal choroidal thickness were assessed. Retrobulbar blood flow were evaluated by measuring peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive index (RI) of ophthalmic artery (OA), central retinal artery (CRA) and short ciliary artery (SCA). In this study, 26 DR patients with a mean age of 56.15 ± 8.93 years and mean diabetes mellitus duration of 15.04 ± 7.64 years were enrolled. Subfoveal choroidal thickness was significantly increased from 316.08 ± 61.69 to 327.81 ± 58.03 after CaD treatment (P value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink