Combinatorial effects of odorants on mouse behavior
| Autor: | Xiaolan Ye, Marcus Hernandez, Luis R. Saraiva, Linda B. Buck, Kunio Kondoh, Kyoung-hye Yoon |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Context (language use) Olfaction Biology Ligands Receptors Odorant Olfactory Receptor Neurons Receptors G-Protein-Coupled Mice 03 medical and health sciences 0302 clinical medicine Immune system Biological neural network Animals Humans Receptor Trace amine-associated receptor Mice Knockout Multidisciplinary Behavior Animal musculoskeletal neural and ocular physiology food and beverages Olfactory Perception Mice Inbred C57BL Smell HEK293 Cells 030104 developmental biology PNAS Plus Odor Odorants Signal transduction Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Proceedings of the National Academy of Sciences. 113 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1605973113 |
| Popis: | The mechanisms by which odors induce instinctive behaviors are largely unknown. Odor detection in the mouse nose is mediated by >1, 000 different odorant receptors (ORs) and trace amine-associated receptors (TAARs). Odor perceptions are encoded combinatorially by ORs and can be altered by slight changes in the combination of activated receptors. However, the stereotyped nature of instinctive odor responses suggests the involvement of specific receptors and genetically programmed neural circuits relatively immune to extraneous odor stimuli and receptor inputs. Here, we report that, contrary to expectation, innate odor-induced behaviors can be context-dependent. First, different ligands for a given TAAR can vary in behavioral effect. Second, when combined, some attractive and aversive odorants neutralize one another's behavioral effects. Both a TAAR ligand and a common odorant block aversion to a predator odor, indicating that this ability is not unique to TAARs and can extend to an aversive response of potential importance to survival. In vitro testing of single receptors with binary odorant mixtures indicates that behavioral blocking can occur without receptor antagonism in the nose. Moreover, genetic ablation of a single receptor prevents its cognate ligand from blocking predator odor aversion, indicating that the blocking requires sensory input from the receptor. Together, these findings indicate that innate odor-induced behaviors can depend on context, that signals from a single receptor can block innate odor aversion, and that instinctive behavioral responses to odors can be modulated by interactions in the brain among signals derived from different receptors. |
| Databáze: | OpenAIRE |
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