NMR assignments and histone specificity of the ING2 PHD finger
| Autor: | Catherine A. Musselman, Alex J. Kuo, Or Gozani, Pedro V. Peña, Tatiana G. Kutateladze |
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| Rok vydání: | 2009 |
| Předmět: |
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Molecular Magnetic Resonance Spectroscopy Amino Acid Motifs Crystallography X-Ray Sensitivity and Specificity Article Histones Histone H3 Mice Nucleosome Animals General Materials Science Histone octamer Binding site Conserved Sequence Homeodomain Proteins Binding Sites biology Chemistry Tumor Suppressor Proteins General Chemistry Reference Standards Chromatin Histone Biochemistry PHD finger biology.protein H3K4me3 Tumor Suppressor Protein p53 |
| Zdroj: | Magnetic resonance in chemistry : MRC. 47(4) |
| ISSN: | 1097-458X |
| Popis: | The ING2 plant homeodomain (PHD) finger is recruited to the nucleosome through specific binding to histone H3 trimethylated at lysine 4 (H3K4me3). Here, we describe backbone and side chain assignments of the ING2 PHD finger, analyze its binding to the unmodified and modified histone and p53 peptides, and map the histone H3 and H3K4me3 binding sites based on chemical shift perturbation analysis. |
| Databáze: | OpenAIRE |
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